IMPORTANT NOTICE ABOUT OESTRUS CONTROL
Megestrol acetate, the active ingredient of Ovarid (now discontinued), has been used by breeders for postponement and prevention of oestrus (calling) in queens for many years. Used correctly at the lowest possible dose for short/medium term oestrus control side effects should not be a problem. However use of progestogens can be associated with adverse effects such as chronic endometrial hyperplasia (thickening of the uterine lining), pyometra and Diabetes mellitus. Breeders should discuss the risks/ benefits of using megestrol in their particular situation with their vets as alternative options may be more suitable depending on their circumstances.
Most breeders find that 1.25mg (1/4 Ovarid) given in anoestrus ( ie when the queen is not calling) will postpone the next oestrus for 2-4 weeks. Individual queens vary in this respect and a few may require a higher dose of 2.5mg.
This is a safer way of using megestrol than giving it when the queen is actually calling when higher doses over 3 consecutive days are required to prevent the call.
Megestrol acetate, can now be made by a licensed UK laboratory (The Specials Laboratory) in 1.25mg capsules equivalent to 1/4 of a 5mg Ovarid tablet.
Unfortunately, as this medicine is made in small batches by a specialist laboratory, the price for direct order by vets in small quantities for individual clients is very expensive so we have negotiated with an approved online pharmacy (Vet Medic) who have agreed to buy in bulk when they receive enough prescriptions. The cost will be approximately £5 per capsule but might be slightly less if enough orders are received.
The procedure for obtaining megestrol from Vet-Medic is detailed below - the shelf life is only 90 days so only order what you can use in that period
The procedure is as follows:
1. Please obtain a prescription from your veterinary surgeon for the number of capsules and dose schedule you require. Please remember the shelf life of the capsules is 90 days
2. The prescription can be sent by email ( scanned copy is acceptable) to orders@vet-Medic.com or by post to:
Vet-Medic Pharmacy, Manor House, Merlin Way, Ilkeston, Derbyshire DE7 4RA
3. Please title your email:PRESCRIPTION MEGESTROL (FAO: A WALTON)
4. Please include your contact details so that the company can get in touch to collect payment when the order is ready.
You can copy and paste the following text into your email if easier:
“Hi Attached is a prescription for 1.25mg megestrol capsules as discussed with Mr Walton. Please contact me when you require payment.My email address is:My telephone/mobile numbers are:”-~~~~~~~~~~~~~~~~~~
Please order as quickly as possible so that you get the maximum shelf life for the capsule.
Risk of antifreeze poisoning in cats
It is a sad fact that, with the arrival of winter comes an increase in the number of cats poisoned by antifreeze.
Cats are particularly susceptible due to their specialised metabolism. Cats only need to drink a teaspoon or less for it to cause serious illness and even death. So a curious lick or two from a small spillage could be enough to cause serious poisoning.
For advice on keeping cats safe, click on this link to International Cat Care's website.
GCCF HCM Policy
BACs which have incidence of HCM occurring with some frequency in their breed are invited to consider the HCM policy (see Link on the left) to consider options for reducing risk. These can be discussed with the GCCF’s Veterinary Officers and Committee. Contact: firstname.lastname@example.org
Levetiracetam shows promise for the treatment of feline audiogenic reflex seizures
A group of UK-based investigators from Davies Veterinary Group and the UCL School of Pharmacy, who recently engaged the veterinary world with an article defining the previously undocumented syndrome of feline audiogenic reflex seizures (FARS), have published follow-up findings about the treatment of the condition. Their paper, 'Levetiracetam in the management of feline audiogenic reflex seizures: a randomised, controlled, open label study', appears in the Journal of Feline Medicine and Surgery*. FARS is a problem of older cats, which typically exhibit myoclonic seizures (brief, shock-like jerks of a muscle or a group of muscles) in response to certain high-pitched sounds. Both non-pedigree and pedigree cats (in particular, Birmans) may be affected.
Lucky escape for 'yellow' cat
Haggis, a striking Maine Coon cat, had a very lucky escape from lily poisoning after brushing up against a bouquet of lilies, the pollen from which turned
hiswhitefuryellow. Had Haggis begun to groom the pollen from his fur, he would almost certainly have suffered kidney damage and may have died. Haggis’s lucky escape was due to the vigilance of this owner, who checked whether lily pollen could be poisonous. As soon as she discovered that the pollen could cause kidney failure if ingested, she immediately washed Haggis and took him straight to the vet where he was put on intravenous fluids and kept in for two days. Fortunately Haggis developed no problems and was allowed home with no adverse effects.
Haggis’s story came to light as part of the charity International Cat Care’s (iCatCare) Keeping Cats Safe campaign, which during the month of September is highlighting the danger lilies pose to cats. Lilies are frequently used in flower arrangements for their attractive appearance and fragrant flowers, however many people are still unaware of the danger they pose to cats. Eating any part of the lily – flowers, leaves, stem or pollen – or even drinking the water from a vase with lilies in it, is extremely dangerous to cats. Once ingested the toxin causes severe damage to the kidneys and in severe cases the kidneys fail completely. Signs of poisoning include drooling, vomiting, refusing food, lethargy and depression and a vet may find enlarged and painful kidneys on examination.
The message of iCatCare’s campaign is that if you own a cat, never keep lilies in the house and should you suspect that your cat has been exposed to lilies, you seek immediate veterinary advice. Claire Bessant, Chief Executive of iCatCare said: ‘The unusual thing about the case of Haggis is that the outcome was good, which sadly is quite often not the case. Many owners are still unaware of the danger of lilies to their cats and cats often die as a result of poisoning. We hope that this campaign and the case of Haggis will highlight the danger.’ iCatCare has put together information for owners and veterinary professionals on its website, including a downloadable ‘lethal lilies’ poster. The charity will continue to raise awareness of this campaign and will be working more closely with supermarkets and florists on clearer labelling of bouquets and flower arrangements which contain lilies.
CONCENTRATED LAUNDRY LIQUID TOXICITY
Following an incident in which 4 Burmese cats suffered serious injury (including one fatality) following contact with accidental spillage of Persil concentrated laundry liquid, I would like to warn cat owners and veterinary surgeons of the danger of all brands of concentrated laundry liquid for pets.
The high concentration of chemicals in these products is extremely irritant to skin and mucous membranes. Skin contact can result in serious burns and if the liquid is ingested it will cause severe irritation of the lining of the gastro-intestinal and respiratory tracts. Cats are especially at risk because of their instinctive tendency to remove any contamination from their fur by licking.
The more costly branded concentrated laundry liquids containing 15-30% anionic detergents are particularly dangerous. Cheaper products containing 5-15% anionic detergents are less dangerous but still irritant.
See full details here
PERMETHRIN POISONING IN CATS
All owners and breeders should be aware of the danger of Permethrin poisoning in cats. Permethrin is the active ingredient of a number of over-the-counter spot-on treatments for the control of fleas in dogs. Permethrin is extremely poisonous to cats. It affects the nervous system and causes severe neurological signs eg fits/seizures and even exposure to small quantities can be fatal. There is no specific antidote.
Many cats have been poisoned as a result of owners failing to read the product instructions properly and applying to cats in error. Cats can also be fatally poisoned by coming into contact with dogs who have been treated by licking the product off the skin or even just by skin contact.
International Cat Care has been very active in persuading the maufacturers to improve the labelling of these products and most do now carry clear conspicuous warnings of the danger to cats on the packaging.
All cat owners should take care that any over-the-counter flea treatment they buy is one that is marketed for use in cats and should always read the label and product literature carefully. It is also strongly recommended that cat owners do not use products containing Permethrin on their dogs. The risk of accidental contact is high, treated dogs pose a risk to cats for up to 72 hours after treatment and plenty of cat-safe alternatives are available. If owners require advice on choice of flea treatment for cats and dogs or control of fleas in general it is recommended they consult their veterinary surgeon, or veterinary pharmacist.
Sue Moreland MRCVS
GCCF Veterinary Officer
4th June 2010
Bristol University Cat Study
Bristol University would appreciate a small amount of time as help from cat owners in the Cat Fancy. For details see here
The Animal Health Trust investigates deafness in white cats
The AHT was one of the first places in the country to offer Brainstem Auditory Evoked Response (BAER) hearing tests in 1992 for cats and dogs for congenital deafness; deafness that is present at birth and therefore likely to be hereditary. Since then, the Trust has pioneered the use of BAER hearing tests to routinely screen litters of kittens and puppies with predominantly white coats to detect those animals that are born deaf.
However, the genetics behind this phenomenon is still unclear. The AHT's new study aims to better understand the prevalence of congenital deafness in white kittens and their litter mates in the UK, and will be a basis to further investigate the genetic heritability and genetic defects behind the disease in white cats in the future.
The study focuses on five breeds: British Shorthair, Norwegian Forest, Russian, Turkish Vankedisi and Maine Coon and needs more participants to aid this research. The AHT is offering breeders a FREE BAER hearing test for the entire litter of kittens, as long as at least one of the litter is completely white.
For more information, or to arrange for your litter to take part in the study, please contact email@example.com or firstname.lastname@example.org of the Neurology Department, or call 01638 552700.
FELINE CORONAVIRUS (FCoV) RESEARCH
Please visit Langford Veterinary Services for more information.
Our study requires tissue samples collected from cats that have died from any cause or disease, and at any age; we are not specifically recruiting FIP cases.
Many thanks again for your help with this research. We hope that it will benefit many cats in the future through its findings.